Antibacterial Mechanism of Dihydrotanshinone I
نویسندگان
چکیده
منابع مشابه
Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza Bunge.
Cryptotanshinone and dihydrotanshinone I, constituents of a medicinal plant, Salvia miltiorrhiza Bunge, had antibacterial activity against a broad range of Gram positive bacteria. These compounds generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was 2- to 8-fold more sensitive than a wild strain, and this hypersensitivity was redu...
متن کاملRegulation of HuR structure and function by dihydrotanshinone-I
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. ...
متن کاملDihydrotanshinone I inhibits angiogenesis both in vitro and in vivo.
Dihydrotanshinone I (DI), a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, has been reported to have cytotoxicity to a variety of tumor cells. In this study, we investigated its anti-angiogenic capacity in human umbilical vein endothelial cells. DI induced a potent cytotoxicity to human umbilical vein endothelial cells, with an IC(50) value of approximately 1.28 microg/m...
متن کاملInhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge.
Dihydrotanshinone I induced topoisomerase I-mediated DNA cleavage in vitro as strongly as camptothecin, but topoisomerase II-mediated DNA cleavage was not affected. In a DNA relaxation assay using calf thymus DNA topoisomerase I and supercoiled pBR322 plasmid DNA, dihydrotanshinone I reduced topoisomerase I-mediated DNA relaxation in a dose-dependent manner. Heat treatment (65°C) of the reactio...
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Polypyrrole-chitosan nanocomposite (PPy-CTN) was synthesized by dispersion polymerization of PPy in presence of CTN. Preparation of spherical PPy nanoparticles that were successfully covered with a thin layer of chitosan was confirm by transmission electron microscopy (TEM) technique. Characterization techniques also revealed the presence of CNT in the polymer matrix and its presence was confir...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2021
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x21996158